THE DIFFERENCE OF EFFECTIVITY BETWEEN MANGOSTEEN PEEL EXTRACT AND METRONIDAZOLE ON FIBROBLAST PROLIFERATION

Adinda Nur Atiqah*    -  , Indonesia
Adisty Restu Poetri    -  Fakultas Kedokteran Gigi Universitas Islam Sultan Agung Semarang, Indonesia
Moh Husnun Niam    -  Fakultas Kedokteran Gigi Universitas Islam Sultan Agung Semarang, Indonesia

(*) Corresponding Author
DOI: 10.30659/odj.8.1.80-85

Background: The disease of the oral cavity is quite common in the society is periodontitis. The main cause of this condition is a certain bacterial infection found in dental plaque. In general, metronidazole gel will be given as additional therapy to treat bacterial colonization. Mangosteen peel extract gel contains xanthones and flavonoids which are known to be antibacterial and anti-inflammatory. This research aims to specify the differences in the effectiveness of anti-inflammatory between mangosteen peel extract and metronidazole gel on fibroblast proliferation.
Method: This is a laboratory experimental design using post-test only design consisted of 50% mangosteen peel extract gel group, 75% mangosteen peel extract gel group, 25% metronidazole gel group and metronidazole plus gel group. This research used male Wistar rats induced periodontitis by ligation for 7 days as samples.
Results: The results reveal that there was a differences in effectiveness between the 4 groups against the proliferation of fibroblast were analyzed using One Way ANOVA with a significance of 0.000 (p<0.05).
Conclusion: It can be concluded that there was differences in the effectiveness of mangosteen peel extract gel and metronidazole gel as anti-inflammatory on proliferation of fibroblast in periodontitis healing process.

Keywords: Mangosteen peel extract gel; metronidazole gel; periodontitis; fibroblast proliferation

  1. Tedjasulaksana R. Metronidasol sebagai salah satu obat pilihan untuk periodontitis marginalis. J Kesehat Gigi. 2016;4:19–23.
  2. Vargas SAI, Ilyina A, Segura CEP, Silva BY, L MG. Etiology and microbiology of periodontal diseases: A review. African J Microbiol Res. 2015;9(48):2300–6.
  3. Newman M, Takei H, Klokkevold P, Carranza F. Carranza Clinical Periodontology 13th ed 2. 2019. 27–33 p.
  4. Murakami S. Dental plaque–induced gingival conditions. J Clin Periodontol. 2018;45(February 2017):S17–27.
  5. Siregar I, Supardan I, Sulistijarso N. Pengaruh Pasta Ekstrak Daun Sukun (ArtocarpusAltilis) terhadap Perubahan Sel Fibroblas dan Jaringan Kolagen pada Periodontitis. J Ris Kesehat. 2015;4(3):786–92.
  6. Abdurrohman MMS, Putranto RR. Metronidazole Gel Effect on Rats With Bacteria-Induced Periodontitis. ODONTO Dent J. 2020;7(1):48.
  7. Quamilla N. Stres Dan Kejadian Periodontitis (Kajian Literatur). J Syiah Kuala Dent Soc. 2016;1(2):161–8.
  8. Haris M, Panickal DM. Role of Metronidazole as a Local Drug Delivery in the Treatment of Periodontitis:A Review. Int J Oral Heal Med Res. 2017;3(July):141–5.
  9. Wijayanto R, Herawati D, Sudibyo. Perbedaan Efektivitas Topikal Gel Asam Hialuronat Dan Gel Metronidazol Terhadap Penyembuhan Jaringan Periodontal Setelah Kuretase Pada Periodontitis Kronis. J Ked Gi [Internet]. 2014;5(3):307–11.
  10. Putri K, Darsono L, Mandalas H. Anti-Inflammatory Properties of Mangosteen Peel Extract on The Mice Gingival Inflammation Healing Process. Padjadjaran J Dent. 2017;29(3):190–5.
  11. Wathoni N, Putri NA, Cahyanto A, Muchtaridi M. Pemanfaatan Manggis Sebagai Sediaan Antiseptik dalam Upaya Peningkatan Kesehatan Masyarakat di Desa Sayang, Jatinangor, Sumedang. Maj Farmasetika. 2020;5(2):57.
  12. Primadina N, Basori A, Perdanakusuma DS. Proses Penyembuhan Luka Ditinjau dari Aspek Mekanisme Seluler dan Molekuler. Qanun Med - Med J Fac Med Muhammadiyah Surabaya. 2019;3(1):31.
  13. Wisuitiprot W, Wisutthathum S, Pitiporn S, Wisuitiprot V, Kwankhao P, Waranuch N. Effect of Garcinia Mangostana Linn Fruit Peel Ethanolic Extract on Fibroblast Cell Migration. Biomed J Sci Tech Res. 2019;19(3).
  14. Widayat MM, Purwanto, Shita A, Dewi P. Daya Antibakteri Infusa Kulit Manggis ( Garcinia mangostana L ) terhadap Streptococcus mutans. e-Jurnal Pustaka Kesehat. 2016;4(3):514–8.
  15. Azzahra H, Pujiastuti P, Purwanto. Potensi Ekstrak Kulit Buah Manggis ( Garcinia mangostana L .) Buatan Pabrik Terhadap Peningkatan Aktivitas Mikrobisidal Sel Neutrofil yang Dipapar Streptococcus mutans. e-Journal Pustaka Kesehat. 2014;2(1):161–6.
  16. Dwintanandi C, Nahzi MYI, Raharja SD. Pengaruh Ekstrak Kulit Manggis (Garcinia mangostana Linn.) Terhadap Jumlah Makrofag Pada Inflamasi Pulpa. J Kedokt Gigi. 2016;I(2):151–7.
  17. Mendes CL, Assis P de, Annibal H, Oliveira LJR de, Albuquerque MS de, Soares M de L, et al. Metronidazole and amoxicillin association in aggressive periodontitis: A systematic review and meta-analysis. Saudi Dent J. 2020;32(6):269–75.
  18. Laut M, Ndaong N, Utami T, Junersi M, Bria Seran Y, Farmakologi dan Toksikologi FKH Undana Jl Adisucipto B, et al. EFEKTIVITAS PEMBERIAN SALEP EKSTRAK ETANOL DAUN ANTING-ANTING (Acalypha indica Linn.) TERHADAP KESEMBUHAN LUKA INSISI PADA MENCIT (Mus musculus) (The Effectiveness of Topical Ointment Containing Ethanolic Extract of Acalypha Indica Leaves on Wound Healing. J Kaji Vet. 2019;7(1):1–11.
  19. Sriyono RAN, Andriani I. Daya Antibakteri Ekstrak Etanol Kulit Manggis (Garcinia Mangostana Linn.) Ter- hadap Bakteri Porphyromonas Gingivalis Antibacterial. Indones Dent J. 2013;2(2):76–82.

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