RECURRENT ORAL ULCERATION (ROU) IN MICROCYTIC HYPOCHROMIC ANEMIA (A CASE REPORT)

Astrid Marinna*  -  Airlangga University, Indonesia
Muhammad Yusri  -  Airlangga University, Indonesia

(*) Corresponding Author

Background: Anemia is a systemic disorder that manifestation in oral cavity; one of the manifestation is ulcerated lesions. It is difficult to heal and the frequency of recurrence is also high, because in anemic condition the oral mucosa susceptible to irritation.
Method: This case report tells about oral mucosal ulceration with a systemic background of Microcytic Hypochromic Anemia triggered by trauma due to orthodontic appliances. Case: A 21-year-old girl with a chief complaint of multiple ulcerated lesions on the upper and lower labial mucosa. The Ulceration has suffered along her childhood. This lesion was diagnosed as Recurrent Oral Ulceration (ROU) with a systemic background of Microcytic Hypochromic Anemia. The treatment are Benzidamine Hcl mouthwash, Triamcinolone Acetonide 0.1% in ora base, Systemic prednisone, Immunomodulators, and Multivitamins.
Result: Decreased recurrence rate of ulcerated lesions
Conclusion: Recurrent Oral Ulceration will easily appear in anemic conditions and difficult to treat

Keywords: Anemia; Ulceration; Recurrence

  1. Scully C. Mouth Ulceration. Ent News,Jul/Aug. 2008; Vol 17(3): 40-42.
  2. Patton L. Hematology Desease, In Greenberg MS and Glick M. Burket’s. Oral medicine diagnosis & treatment. 11th ed. Hamilton: BC Decker. 2008: 385-410.
  3. Woo S.B and Greenberg MS. Ulcerative, vesicular, and bullous lesions of the Oral mucosa, In Greenberg MS and Glick M. Burket’s. Oral medicine diagnosis & treatment. 11th ed. Hamilton: BC Decker. 2008: 57-60.
  4. Scully C and Porter S. Oral mucosal disease: Recurrent aphthous stomatitis. British Journal of oral and Maxillofacial Surgery. 2008; 46: 198-206.
  5. Shashy R and Ridley M. Aphthous Ulcers: A Difficult Clinical Entity. American Journal of Otolaryngology. 2000; 21(6): 389-393.
  6. Field A and Longman L. Oral Ulcerartion, in Tyldesley’s Oral medicine. 5th ed. Oxford: University Press; New York. 2003: 50-56.
  7. Preeti L. Recurrent Apthous Stomatitis, in Journal of Oral Maxillofacial Pathology. 2011; 13 : 252-256.
  8. Ganda K. Anemia. Available at http://www.ocw.tufts.edu/Content/24/lecturenotes/312664.htm. Accessed July 10, 2009.
  9. Conrad ME. Anemia. Available at http://www.emedicine.com/med/topic132.htm. Accessed January 15, 2008.
  10. Thongprasom K, Youngnak P and Aneksuk V. Hematologic abnormalities, in Recurrent Oral Ulceration. Southeast Asian J Trop Med Public Health. 2002; Vol 33(4): 872-7.
  11. Chakrabarty A .Aphthous Ulcers Associated With Imiquimod And The Treatment Of Actinic Cheilitis. The American Academy of Dermatology, Inc. doi:10.1016/j.jaad. 2004; 6:45.
  12. Killip S, Bennett JM, Chambers MD. Iron deficiency anemia. Am Fam Physician. 2007; 75: 671-8.
  13. Scully C. Aphthous ulceration. New England Journal Med. 2006; 355(2): 165-172.
  14. Anonymous Recurrent Oral Ulceration. Available at: http://www.baoms.org.uk.document.html.pdf. Accessed July 15, 2009.
  15. Simon H. Anemia. Available at http://www.adam.about.com/reports/Anemia.htm. Accessed July 28, 2008.
  16. Neville BW, Damm DD, Allen CM and Bouquot JE. Oral and Maxillofacial Pathology. 2nd ed. Philadelphia: Saunders Co. 2002: 285-90.
  17. Garcia, A Case Report Of Pernicious Anemia And Recurrent Apthous Stomatitis, The Journal of Contemporary Dental Practice. 2009, Vol 10(2): 223-226.
  18. Titilope A Adeyemo, Wasiu L Adeyemo, Adewumi Adediran, Abd Jaleel A Akinbami and Alani S Akanmu. Orofacial Manifestations Of Hematological Disorders, In Anemia and hemostatic disorders. Departments of Haematology and Blood Transfusion and Oral and Maxillofacial Surgery. College of Medicine. University of Lagos, Nigeria. 2011; Vol 22 (3): 454-461.
  19. Vikrant Kale and Abdur Rahmaan Aftab. Diagnostic Evaluation of Anaemia, in Anemia. 2012: 75-91.
  20. Simon H. Health Guide Anemia, in New York times. Available at http://www.nytimes.com/health/guides/disease/anemia/complications.html (Accessed : 16/ 5/2014).
  21. Pedoman Interpretasi Data Klinik, Surat Keputusan Direktur Jenderal Bina Kefarmasian Dan Alat Kesehatan Nomor : Hk.03.05/Iii/571/II Kementerian Kesehatan Republik Indonesia. Jakarta, Pada tanggal : 19 Oktober 2011.
  22. Sabari N. Anemia. Medical Officer at Sugavazhvu Health Care Private Limited on Aug 09. Available at http://www.slideshare.net/sabisiddh/anemia-25085879 (Accesed: 30/10/14)
  23. Koss W. Anemias of abnormal iron Metabolism and Hemochromatosis, In: Koepke JA, Martin EA, Steininger CA eds. Clinical Haematology, Principles Procedures and Correlation, 9th edition, Lippincot Philadelphia. 1998: 979-1010.
  24. Delong L. General and Oral Pathology for the Dental Hyginest,. Wolrwes Kluwer Health. The point. Colombi. 2009: 57,2011.
  25. Terapi Hiperbaric Oxygen Therapy. Terdapat di: htpp://kesehatan.kompasiana.com/2012/02/25/terapi-hiperbarik-oksigen-solusi-sehat-tni-angkatan-laut-surabaya/ diakses tanggal 19 Mei 2014.
  26. Bakta IM.Hematologi Klinik.Jakarta. EGC; 2007: 26-42.
  27. Muhammad Dan Sianipar. Penentuan Defisiensi Besi Anemia Penyakit Kronis Menggunakan Peran Indeks Stfr-F(Determination Of Iron Deficiency In Chronic Disease Anemia By The Role Of Stfr-F Index)Indonesian Journal Of Clinical Pathology And Medical Laboratory, Vol.12 (1); Nov 2005: 9-15.
  28. Kasper L.D, Braunwald E, Fauci A, Hauser S.L, Longo D.L, and Jameson, J.L. Harrison’s Manual of Medicine 16thed. McGraw-Hill Medical Publishing Division. 2005; 12: 615-807.

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