An Overview of antibiotic prescription after tooth extraction across dentist in Bandung City, Indonesia: A Cross-Sectional Study

Zahrah Diva Shasya*  -  Padjajaran University, Indonesia
Farah Asnely Putri    -  Universitas Padjajaran, Indonesia
Indra Hadikrishna    -  Universitas Padjajaran, Indonesia

(*) Corresponding Author

Background: Tooth extraction is one of minor oral surgical procedure and antibiotics are commonly prescribed before or after the tooth extraction procedure. Antibiotic is used as therapy or to prevent infections after tooth extractions. Recent studies discovered that misuse of antibiotics by dentists has been an issue nowadays. The purpose of this study is to investigate the frequency and varieties of antibiotics post tooth extraction used by dentists in Bandung City.
Method: This study uses a quantitative descriptive method with a cross-sectional approach using a questionnaire. The samples in this study are general dentists and specialists in Bandung. The questionnaire was sent to dentists using proportionate stratified random sampling.
Result: The most frequently used antibiotics in Bandung City are Amoxicillin 500 mg (83,1%) and Clindamycin (24,3%). Most respondents prescribed antibiotics after tooth extractions for 5 days.
Conclusion: A small percentage of Dentists in Bandung City still prescribed antibiotics in conditions that do not always require antibiotics, such as simple post-extraction, irreversible pulpitis, and reversible pulpitis. Broad-spectrum antibiotics are more commonly prescribed to prevent infections. Furthermore, antibiotic usage after simple tooth extraction needs to be done by considering the patient’s condition, diagnosis, and difficulty level of extraction.

Keywords: Antibiotic; tooth extraction; dentists; bandung city

  1. Halling F, Neff A, Heymann P, Ziebart T. Trends in antibiotic prescribing by dental practitioners in Germany. J Cranio-Maxillofacial Surg [Internet]. 2017;45(11):1854–9. Available from: http://dx.doi.org/10.1016/j.jcms.2017.08.010
  2. Lalloo R, Solanki G, Ramphoma K, Myburgh NG. Antibiotic-prescribing patterns of South African dental practitioners following tooth extractions. J Investig Clin Dent. 2016;8(4):1–6.
  3. Lodi G, Figini L, Sardella A, Carrassi A, Del Fabbro M, Furness S. Antibiotics to prevent complications following tooth extractions. Cochrane Database Syst Rev. 2012;2012(11).
  4. Stein K, Farmer J, Singhal S, Marra F, Sutherland S, Quiñonez C. The use and misuse of antibiotics in dentistry: A scoping review. J Am Dent Assoc [Internet]. 2018;149(10):869-884.e5. Available from: https://doi.org/10.1016/j.adaj.2018.05.034
  5. Isik BK, Gürses G, Menziletoglu D. Acutely infected teeth: to extract or not to extract? Braz Oral Res. 2018;32:e124.
  6. Richardson WL, Hammert WC. Adverse effects of common oral antibiotics. J Hand Surg Am [Internet]. 2014;39(5):989–91. Available from: http://dx.doi.org/10.1016/j.jhsa.2014.01.021
  7. Gavazova G, Hristozova E, Kisselov S, Raycheva R, Pechalova P. Bacteremia Following Closed and Open Dental Extraction. Folia Med (Plovdiv). 2019;61(4):600–4.
  8. Oberoi SS, Dhingra C, Sharma G, Sardana D. Antibiotics in dental practice: How justified are we. Int Dent J. 2015;65(1):4–10.
  9. Organization WH. The world medicines situation: rational use of medicines. World Med Situat. 2011;2(2):24–30.
  10. Setiawan E, Wibowo YI, Setiadi AP, Nurpatria Y, Sosilya H, Wardhani DK, et al. Implementasi Antimicrobial Stewardship Program di Kawasan Asia: Sebuah Kajian Sistematis. Indones J Clin Pharm. 2019;8(2):141.
  11. Marra F, George D, Chong M, Sutherland S, Patrick DM. Antibiotic prescribing by dentists has increased Why? J Am Dent Assoc [Internet]. 2016;147(5):320–7. Available from: http://dx.doi.org/10.1016/j.adaj.2015.12.014
  12. Manginar Sidabutar, Friska D Simamora, Faber Sidabutar, Yuliana R Dolo Wain MEM, Department. The Rational Use of Antibiotics by Dentists for Odontogenic Infection Treatment. 2019;50–5.
  13. Choi YY. Prescription of antibiotics after tooth extraction in adults: A nationwide study in Korea. J Korean Assoc Oral Maxillofac Surg. 2020;46(1):49–57.
  14. Teoh L, Stewart K, Marino R, McCullough M. Antibiotic resistance and relevance to general dental practice in Australia. Aust Dent J. 2018;63(4):414–21.
  15. Yousuf W, Khan M, Mehdi H, Mateen S. Necessity of Antibiotics following Simple Exodontia. Scientifica (Cairo). 2016;2016.
  16. Melander RJ, Zurawski D V., Melander C. Narrow-spectrum antibacterial agents. Medchemcomm. 2018;9(1):12–21.
  17. Organization WH. Antimicrobial resistance: global report on surveillance [Internet]. World Health Organization. 2014. Available from: https://www.who.int/drugresistance/documents/surveillancereport/en/
  18. Sabtu N, Enoch DA, Brown NM. Antibiotic resistance: What, why, where, when and how? Br Med Bull. 2015;116(1):105–13.
  19. Organization WH. The Evolving Threat of Antimicrobial resistance : options for action [Internet]. Geneva : World Health Organization. 2012. Available from: https://www.researchgate.net/publication/271851729_The_Evolving_Threat_of_Antimicrobial_Resistance_Options_for_Action
  20. de Kraker MEA, Stewardson AJ, Harbarth S. Will 10 Million People Die a Year due to Antimicrobial Resistance by 2050? PLoS Med. 2016;13(11):1–6.
  21. Babatunde OA, Babatope BO. Is routine antibiotic prescription following exodontias necessary? A randomized controlled clinical study. J Dent Oral Hyg. 2015;7(1):1–8.
  22. Jain KM, Oswal S. Antibiotics in Dentistry - An Art and Science. 2013.
  23. Karki AJ, Holyfield G, Thomas D. Dental prescribing in Wales and associated public health issues. Br Dent J. 2011;210(1).
  24. Sarmiento MA, Maglutac Jr MT, Yanga-Mabunga MS. Antibiotic prescribing practices of Filipino Dentists. Int J Public Heal Sci. 2019;8(3):332.
  25. Riskesdas. Laporan Provinsi Jawa Barat. Lembaga Penerbit Badan Penelitian dan Pengembangan Kesehatan. 2018. 140–151 p.
  26. Prasad N, Visalakshi D, Chaitan SM, Prasad SR, Reddy LVK, Kumar KA. Rationale of Antibiotic Usage in Simple Exodontia – a Prospective Study. Int J Sci Res Publ. 2019;9(8):p9238.
  27. Vettori E, Costantinides F, Nicolin V, Rizzo R, Perinetti G, Maglione M, et al. Factors influencing the onset of intra-and post-operative complications following tooth exodontia: Retrospective survey on 1701 patients. Antibiotics. 2019;8(4).
  28. Ogle OE. Odontogenic Infections. Dent Clin North Am [Internet]. 2017;61(2):235–52. Available from: http://dx.doi.org/10.1016/j.cden.2016.11.004
  29. Huttner A, Bielicki J, Clements MN, Frimodt-Møller N, Muller AE, Paccaud JP, et al. Oral amoxicillin and amoxicillin–clavulanic acid: properties, indications and usage. Clin Microbiol Infect [Internet]. 2020;26(7):871–9. Available from: https://doi.org/10.1016/j.cmi.2019.11.028
  30. Durkin MJ, Hsueh K, Sallah YH, Feng Q, Jafarzadeh SR, Munshi KD, et al. An evaluation of dental antibiotic prescribing practices in the United States. J Am Dent Assoc [Internet]. 2017;148(12):878-886.e1. Available from: http://dx.doi.org/10.1016/j.adaj.2017.07.019
  31. Kementerian Kesehatan Republik Indonesia. Modul penggunaan obat rasional. Kementeri Kesehat RI. 2011;1–192.
  32. Kaul R, Angrish P, Saha S, Sengupta A V, Mukherjee S. A Survey on the Use of Antibiotics among the Dentists of Kolkata, West Bengal, India. Int J Clin Pediatr Dent. 2018;11(2):122–7.
  33. Yagiela JA, Dowd FJ, Johnson BS, Mariotti AJ, Neidle EA. Pharmacology and Therapeutics For Dentistry. Mosby Elsevier; 2011. 957 p.
  34. Nikolaus O Palmer. Antimicrobial Prescribing in Dentistry: Good Practice Guidelines. Faculty of General Dental Practice (UK) and Faculty of Dental Surgery. 2020. 49–63 p.
  35. Bassetti M, Montero JG, Paiva JA. When antibiotic treatment fails. Intensive Care Med. 2018;44(1):73–5.
  36. Ahmadi H, Ebrahimi A, Ahmadi F. Antibiotic Therapy in Dentistry. Int J Dent. 2021;2021.
  37. Dar-Odeh N, Abu-Hammad, Al-Omiri, Khraisat, Shehabi. Antibiotic prescribing practices by dentists: a review. Ther Clin Risk Manag. 2010;301.
  38. Perić M, Perković I, Romić M, Simeon P, Matijević J, MehiÄić GP rpi., et al. The Pattern of Antibiotic Prescribing by Dental Practitioners in Zagreb, Croatia. Cent Eur J Public Health [Internet]. 2015;23(2):83–9. Available from: https://doi.org/10.21101/cejph.a3981
  39. Dhanvanth M, Ganapathy D, Jain AR. Choice of antibiotics in the management of dentoalveolar abscess among dental practitioners. Drug Invent Today. 2018;10(12):2390–4.
  40. Peedikayil FC. Antibiotics in Odontogenic Infections - An Update. J Antimicrob Agents. 2016;2(2).
  41. Agnihotry A, Gill KS, Stevenson RG, Fedorowicz Z, Kumar V, Sprakel J, et al. Irreversi bl e pulpitis – A source of antibiotic over-prescription? Braz Dent J. 2019;30(4):374–9.
  42. Agnihotry A, Thompson W, Fedorowicz Z, van Zuuren EJ, Sprakel J. Antibiotic use for irreversible pulpitis. Cochrane Database Syst Rev. 2019;2019(5).
  43. Agrawal M, Rahman QB, Akhter M. Extraction of Asymptomatic Tooth With And Without Antibiotic Therapy. Bangabandhu Sheikh Mujib Med Univ J. 2012;5(1).
  44. Oei A, Hülsmann M. The acute apical abscess: aetiology, microbiology, treatment and prognosis. Endo (l Engl). 2018;12(2):75–85.
  45. Atif M, Asghar S, Mushtaq I, Malik I, Amin A, Babar ZUD, et al. What drives inappropriate use of antibiotics? A mixed methods study from Bahawalpur, Pakistan. Infect Drug Resist. 2019;12:687–99.
  46. Cope AL, Chestnutt IG. Inappropriate prescribing of antibiotics in primary dental care: reasons and resolutions. Prim Dent J. 2014;3(4):33–7.
  47. Alsaleh MK, Alajlan SS, Alateeq NF, Alamer NS, Alshammary F, Alhobeira HA, et al. Alveolar Osteitis: Patient’s compliance with post-extraction instructions following permanent teeth extraction. J Contemp Dent Pract. 2018;19(12):1518–25.
  48. Deliverska EG, Petkova M. Complications After Extraction of Impacted Third Molars - Literature Review. J IMAB - Annu Proceeding (Scientific Pap. 2016;22(3):1202–11.
  49. Malinda Yuti, Prisinda Diani. The Antibiotics Sensitivity Test On Staphylococcus and Streptococcus From Chronic Apical Abscess. Odonto Dental Journal Vol 9 No 1. July 2022

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