- Indonesia
Interleukin-6 (IL-6), Interleukin-8 (IL-8), and Tumor Necrosis FactorAlpha (TNF-a): Their Role in the Development and Metastasis of Tumor Cells
ABSTRACT: Cancer is a disease caused by uncontrolled and excessive cell division. The death caused by cancer is largely due to the cancer cell metastasis process. Cancer metastasis process is a consequence of molecules signaling pathways and interactions amongst cells in the body. Molecules involved and attributable to cancer metastasis are IL-6, IL-8, and TNF-α. This article aimed to describe the roles of IL-6, IL-8, and TNF-α in the process of various cancer cases.
Keywords: cancer, IL-6, IL-8, TNF-alpha, metastasis
- Caminero, A., Comabella, M. and Montalban, X. (2011) ‘Tumor necrosis factor alpha ( TNF- α), anti-TNF- α and demyelination revisited : An ongoing story’, Journal of Neuroimmunology. Elsevier B.V., 234(1–2), pp. 1–6. doi: 10.1016/ j.jneuroim.2011.03.004.
- Chaffer, C. L. and Weinberg, R. A. (2011) ‘A Perspective on Cancer’, Science, 331, pp. 1559–1565. Chaudhuri, P. K., Low, B. C. and Lim, C. T. (2018) ‘Mechanobiology of Tumor Growth’, Chemical Reviews. American Chemical Society, 118, pp. 6499–6515. doi: 10.1021/acs. chemrev.8b00042.
- Chen, D. et al. (2012) ‘LIFR is a breast cancer metastasis suppressor upstream of the Hippo-YAP pathway and a prognostic marker’, Nature Medicine, 18(10), pp. 1511–1517. doi: 10.1038/nm.2940.
- Clevers, H. (2011) ‘Review the cancer stem cell : Premises , promises and challenges’, Nature Medicine. Nature Publishing Group, 17(3), pp. 313–319. doi: 10.1038/nm.2304.
- Dembic, Z. (2015) The Cytokines of the Immune System: The Role of Cytokines in Disease Related to Immune Response. USA: ELSIVIER.
- Dicato, M. A. and Cutsem, E. Van (2018) Side Effects of Medical Cancer Therapy. 2nd edn. Switzerland: Springer International Publishing AG. Feng, W. et al. (2018) ‘HIF-1 α promotes the migration and invasion of hepatocellular carcinoma cells via the IL-8 – NF- κ B axis’, Cellular & Molecular Biology Letters. Cellular & Molecular Biology Letters, 23(26), pp. 1–8. doi: 10.1186/s11658- 018-0077-1.
- Gong, J. et al. (2018) ‘Development of PD-1 and PD-L1 inhibitors as a form of cancer immunotherapy : a comprehensive review of registration trials and future considerations’, Journal for ImmunoTherapy of Cancer. Journal for ImmunoTherapy of Cancer, 6(1), pp. 1–18. doi: 10.1186/s40425-018-0316-z.
- Hanahan, D. and Coussens, L. M. (2012) ‘Accessories to the Crime : Functions of Cells Recruited to the Tumor Microenvironment’, Cancer Cell. Elsevier Inc., 21(3), pp. 309–322. doi: 10.1016/ j.ccr.2012.02.022.
- Hanahan, D. and Weinberg, R. A. (2011) ‘Review Hallmarks of Cancer : The Next Generation’, Cell. Elsevier Inc., 144(5), pp. 646–674. doi: 10.1016/j.cell.2011.02.013. Heerboth, S. et al. (2015) ‘EMT and tumor metastasis’, Clinical and Translational Medicine, 4(6), pp. 1– 13. doi: 10.1186/s40169-015-0048-3.
- Hou, L. et al. (2018) ‘IL-6 Triggers the Migration and Invasion of Oestrogen Receptor Negative Breast Cancer Cells via Regulation of Hippo Pathways’, Basic & clinical pharmacology & toxicology, (January). doi: 10.1111/bcpt.13042.
- Hunter, C. A. and Jones, S. A. (2015) ‘IL-6 as a keystone cytokine in health and disease’, Nature Publishing Group. Nature Publishing Group, 16(5), pp. 448–457. doi: 10.1038/ni.3153.
- Ichim, G. and Tait, S. W. G. (2016) ‘A fate worse than death: apoptosis as an oncogenic process’, Nature Review. Nature Publishing Group, 16(8), pp. 539–548. doi: 10.1038/nrc.2016.58.
- Jayatilaka, H. et al. (2017) ‘Synergistic IL-6 and IL-8 paracrine signalling pathway infers a strategy to inhibit tumour cell migration’, Nature Communications. Nature Publishing Group, 8, pp. 1–12. doi: 10.1038/ncomms15584.
- Jia, L. et al. (2018) ‘IL - 8 is upregulated in cervical cancer tissues and is associated with the proliferation and migration of HeLa cervical cancer cells’, Oncology Letters, 15, pp. 1350– 1356. doi: 10.3892/ol.2017.7391.
- Karaman, S. et al. (2014) ‘Mechanisms of lymphatic metastasis Find the latest version : Review series Mechanisms of lymphatic metastasis’, The Journal of Clinical Investigation, 124(3), pp. 922–928. doi: 10.1172/JCI71606.922.
- Kasper, D. L. et al. (2015) Harrison’s Principle of Internal Medicine 19th ed. Edited by D. L. Kasper et al. New York: Mc Graw Hill Education.
- KEMENKES (2013) Riset Kesehatan Dasar 2013. Jakarta: Badan Penelitian Dan Pengembangan Kesehatan RI.
- Kidd, S. et al. (2012) ‘Origins of the Tumor Microenvironment : Quantitative Assessment of Adipose-Derived and Bone Marrow – Derived Stroma’, PLoS ONE, 7(2). doi: 10.1371/journal. pone.0030563.
- Lamouille, S., Xu, J. and Derynck, R. (2014) ‘Molecular mechanisms of epithelial – mesenchymal transition’, Nature Publishing Group. Nature Publishing Group, 15(3), pp. 178–196. doi: 10.1038/nrm3758.
- Langley, R. R. and Fidler, I. J. (2011) ‘The seed and soil hypothesis revisited — The role of tumorstroma interactions in metastasis to different organs’, International Journal of Cancer, 2535, pp. 2527–2535. doi: 10.1002/ijc.26031.
- Liu, D. (2018) Tumors and Cancers: Head–Neck–Heart– Lung–Gut. Boca Raton: CRC Press, Taylor & Francis Group. Liu, H. and Lathia, J. D. (2016) Cancer Stem Cells: Targeting the Roots of Cancer, Seeds of Metastasis, and Sources of Therapy Resistance. London: ELSIVIER.
- Maolake, A. et al. (2018) ‘Tumor necrosis factor- a induces prostate cancer cell migration in lymphatic metastasis through CCR7 upregulation’, Cancer science, 109, pp. 1–8. doi: 10.1111/cas.13586.
- Marusyk, A. and Polyak, K. (2010) ‘Tumor heterogeneity: Causes and consequences’, BBA - Reviews on Cancer. Elsevier B.V., 1805(1), pp. 105–117. doi: 10.1016/j.bbcan.2009.11.002.
- Medina-ramirez, C. M. et al. (2011) ‘Apoptosis Inhibitor ARC Promotes Breast Tumorigenesis , Metastasis , and Chemoresistance’, Tumor and Stem Cell Biology, 16, pp. 7705–7715. doi: 10.1158/0008- 5472.CAN-11-2192.Apoptosis.
- Moses, C. et al. (2018) ‘Hallmarks of cancer: The CRISPR generation’, European Journal of Cancer. Elsevier Ltd, 93, pp. 10–18. doi: 10.1016/ j.ejca.2018.01.002.
- National Cancer Institute (2018) ‘Types of Cancer Treatment’. Nieman, K. M. et al. (2011) ‘letterS Adipocytes promote ovarian cancer metastasis and provide energy for rapid tumor growth’, Nature Medicine, 17(11), pp. 1498–1503. doi: 10.1038/nm.2492.
- Qin, X. et al. (2018) ‘Cancer-associated Fibroblastderived IL-6 Promotes Head and Neck Cancer Progression via the Osteopontin-NF-kappa B Signaling Pathway’, Theranostics, 8(4), pp. 921– 940. doi: 10.7150/thno.22182.
- Ray, A. L. et al. (2017) ‘This article is protected by copyright. All rights reserved.’, International Journal of Cancer, pp. 1–33. Razidlo, G. L., Burton, K. M. and Mcniven, M. A. (2018) ‘Interleukin-6 promotes pancreatic cancer cell migration by rapidly activating the small GTPase CDC42’, JBC, (3). doi: 10.1074/jbc. RA118.003276.
- Rhim, A. D. et al. (2012) ‘EMT and Dissemination Precede Pancreatic Tumor Formation’, Cell, 148(1–2), pp. 349–361. doi: 10.1016/ j.cell.2011.11.025.
- Singh, M. et al. (2017) ‘EMT: mechanisms and therapeutic implications Mohini’, Pharmacology and Therapeutics. Elsevier Inc. doi: 10.1016/j. pharmthera.2017.08.009.
- Skvortsov, S. et al. (2014) ‘Crosstalk between DNA repair and cancer stem cell (CSC) associated Intracellular pathways’, Seminars in Cancer Biology. Elsevier Ltd. doi: 10.1016/j.semcancer.2014.06.002. Su, S. et al. (2016) ‘Cancer metastasis: mechanisms of inhibition by melatonin’, Journal of pineal research, 62(1). doi: 10.1111/jpi.12370.
- Taniguchi, K. and Karin, M. (2014) ‘IL-6 and related cytokines as the critical lynchpins between inflammation and cancer’, Seminars in Immunology. Elsevier Ltd, 26(1), pp. 54–74. doi: 10.1016/j.smim.2014.01.001.
- World Health Organization (WHO) (2018) Cancer. Available at: www.who.int/cancer/en/.
- Wu, Y. and Zhou, B. P. (2010) ‘TNF- a / NF- k B / Snail pathway in cancer cell migration and invasion’, British Journal of Cancer, 102, pp. 639–644. doi: 10.1038/sj.bjc.6605530.
- Yang, L., Pang, Y. and Moses, H. L. (2010) ‘TGF- b and immune cells : an important regulatory axis in the tumor microenvironment and progression’, Trends in Immunology. Elsevier Ltd, 31(6), pp. 220–227. doi: 10.1016/j.it.2010.04.002.
- Yoshimoto, T. and Yoshimoto, T. (2014) Cytokine Frontiers: Regulation of Immune Response in Health and Disease. Tokyo: Springer Japan. doi: 10.1007/978-4-431-54442-5.
- Yu, H. et al. (2014) ‘Revisiting STAT3 signalling in cancer : new and unexpected biological functions’, Nature Publishing Group. Nature Publishing Group, 14(11), pp. 736–746. doi: 10.1038/nrc3818.
- Zhao, P. and Zhang, Z. (2018) ‘TNF- α promotes colon cancer cell migration and invasion by upregulating TROP-2’, Oncology Letters, pp. 3820–3827. doi: 10.3892/ol.2018.7735.
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